DNA Repair Pathways
DNA repair pathways are a collection of cellular mechanisms that detect and correct damage in DNA to maintain genome integrity and ensure proper cellular function. DNA damage can arise from internal processes such as replication errors and oxidative stress, or external factors like radiation and chemical exposure. To counteract this, cells employ several highly coordinated repair systems, including base excision repair (BER) for small base lesions, nucleotide excision repair (NER) for bulky DNA damage, mismatch repair (MMR) for replication errors, and double-strand break repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ). These pathways play a critical role in preventing mutations, maintaining genomic stability, and reducing the risk of diseases such as cancer.
DNA Repair Pathways DNA Damage Repair Base Excision Repair (BER) Nucleotide Excision Repair (NER) Mismatch Repair (MMR) Homologous Recombination (HR) Non-Homologous End Joining (NHEJ) DNA Damage Response Genome Stability Mutation Prevention Molecular Genetics Cancer Biology
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