Skip to main content

Passenger Mutations

 Passenger Mutations

Passenger mutations are genetic alterations that arise during cancer development but do not provide a selective growth advantage to tumor cells. Unlike driver mutations, passenger mutations do not directly contribute to tumor initiation or progression; instead, they accumulate as a byproduct of genomic instability and repeated cell divisions. Although historically considered biologically neutral, recent studies suggest that some passenger mutations may influence tumor behavior indirectly by affecting cellular fitness, immune recognition, or treatment response. Passenger mutations are widely studied in cancer genomics to distinguish clinically relevant driver events from background mutational noise and to better understand tumor evolution.

Passenger Mutations Cancer Genomics Somatic Mutations Driver vs Passenger Mutations Genomic Instability Tumor Evolution Mutational Burden Clonal Evolution Cancer Genome Molecular Oncology

#PassengerMutations#CancerGenomics#SomaticMutations#TumorEvolution#GenomicInstability#MolecularOncology#PrecisionOncology#CancerResearch#BiomedicalResearch

International Conference on Genetics and Genomics of Diseases 

Visit: genetics-conferences.healthcarek.com

Award Nomination: genetics-conferences.healthcarek.com/award-nomination/?ecategory=Awards&rcategory=Awardee

Award registration: genetics-conferences.healthcarek.com/award-registration/ 

For Enquiries: support@healthcarek.com 

Get Connected Here 
--------------------------------- 
--------------------------------- 
in.pinterest.com/Dorita0211 
twitter.com/Dorita_02_11_ 
facebook.com
linkedin.com/in/genetics-r/profile.php?id=61555903296992 

instagram.com/p/C4ukfcOsK36 
genetics-awards.blogspot.com/

Comments

Post a Comment

Popular posts from this blog

Genetic factors with clinical trial stoppage

Genetic factors associated with reasons for clinical trial stoppage Many drug discovery projects are started but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the free-text reasons for 28,561 clinical trials that stopped before their endpoints were met. We then evaluated these classes in light of the underlying evidence for the therapeutic hypothesis and target properties. We found that trials are more likely to stop because of a lack of efficacy in the absence of strong genetic evidence from human populations or genetically modified animal models. Furthermore, certain trials are more likely to stop for safety reasons if the drug target gene is highly constrained in human populations and if the gene is broadly expressed across tissues. These results support the growing use of human genetics to ...
Post a Comment
Read more

Fruitful innovation

Fruitful innovation: Transforming watermelon genetics with advanced base editors The development of new adenine base editors (ABE) and adenine-to-thymine/ guanine base editors (AKBE) is transforming watermelon genetic engineering. These innovative tools enable precise A:T-to-G and A:T-to-T base substitutions, allowing for targeted genetic modifications. The research highlights the efficiency of these editors in generating specific mutations, such as a flowerless phenotype in ClFT (Y84H) mutant plants. This advancement not only enhances the understanding of gene function but also significantly improves molecular breeding, paving the way for more efficient watermelon crop improvement. Traditional breeding methods for watermelon often face challenges in achieving desired genetic traits efficiently and accurately. While CRISPR/Cas9 has provided a powerful tool for genome editing, its precision and scope are sometimes limited. These limitations highlight the need for more advanced gene-e...
Post a Comment
Read more

Genetics study on COVID-19

Large genetic study on severe COVID-19 Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal " Human Genetics and Genomics Advances ". Even though the number of severe cases following infection with the SARS-CoV-...
Post a Comment
Read more