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Long-Read Sequencing

Long-Read Sequencing

Long-read sequencing is an advanced DNA and RNA sequencing approach that generates reads typically ranging from several kilobases to over 100 kilobases in length. Unlike short-read technologies, long-read sequencing enables accurate resolution of repetitive regions, structural variants, haplotypes, and complex genomic rearrangements. This technology has transformed genome assembly, transcriptome profiling, and epigenetic analysis by providing more contiguous and biologically informative sequences. Major long-read sequencing platforms include Pacific Biosciences (SMRT sequencing) and Oxford Nanopore Technologies, both of which allow real-time, single-molecule sequencing without PCR amplification. Long-read sequencing is increasingly applied in clinical genomics, cancer research, and population studies.

Long-Read Sequencing Single-Molecule Sequencing Genome Assembly Structural Variant Detection Haplotype Phasing Epigenetic Analysis Transcriptomics PacBio SMRT Sequencing Nanopore Sequencing Advanced Genomics

#LongReadSequencing#Genomics#DNASequencing#SingleMoleculeSequencing#StructuralVariants#GenomeAssembly#Transcriptomics#PrecisionMedicine#BiomedicalResearch

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