International Genetics and Genomics of Diseases

Skeletal Abnormalities images  Skeletal abnormalities refer to a broad range of disorders affecting the development, structure, alignment, or integrity of bones and joints. These conditions may be congenital or acquired and can result from genetic mutations , metabolic imbalances , nutritional deficiencies, trauma, infections, or environmental factors. Skeletal abnormalities often impact growth, mobility, posture, and overall quality of life, presenting as deformities, bone fragility, joint dysfunction, or abnormal bone density. Advances in imaging, molecular genetics , and regenerative medicine have significantly improved early diagnosis, classification, and management of skeletal disorders, enabling targeted therapeutic and preventive strategies. Skeletal abnormalities, bone deformities, congenital skeletal disorders, musculoskeletal disorders, bone development, skeletal dysplasia, orthopedic conditions #SkeletalAbnormalities #BoneDisorders #MusculoskeletalHealth #SkeletalDysp...

 Plasma Metabolomics of Broiler Chickens Plasma metabolomics of broiler chickens is a powerful analytical approach used to profile small-molecule metabolites circulating in the blood to better understand physiological, nutritional , and metabolic states. By applying advanced techniques such as liquid chromatography–mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR), researchers can identify metabolic changes associated with growth performance, feed efficiency, immune response, gut health, heat stress, and disease conditions. This approach provides insights into how diet formulations, feed additives, environmental stressors, and genetic factors influence metabolic pathways, enabling precision nutrition and improved poultry health management. Plasma metabolomics, broiler chickens, metabolic profiling, poultry nutrition, LC-MS, NMR spectroscopy, feed efficiency, growth performance, immune response, stress biomarkers #PlasmaMetabolomics #BroilerChickens #PoultryScience ...

 Myoepithelial Carcinoma Myoepithelial carcinoma is a rare and aggressive malignant tumor arising from myoepithelial cells , most commonly affecting the salivary glands, particularly the parotid gland, though it can also occur in soft tissues, breast, lung, and skin. The tumor is characterized by diverse histological patterns, including spindle, plasmacytoid, epithelioid, and clear cells , often showing infiltrative growth and cellular atypia. Clinically, myoepithelial carcinoma may present as a painless, slowly enlarging mass but has a significant potential for local recurrence and distant metastasis. Diagnosis relies on histopathology supported by immunohistochemical markers such as S-100, cytokeratins, p63, calponin, and smooth muscle actin. Surgical excision with clear margins is the primary treatment, often combined with radiotherapy in advanced or recurrent cases. Early detection and accurate pathological assessment are critical for improving patient outcomes. Myoepithelia...

 Pancreatic Cancer Pancreatic cancer is a malignant disease that originates in the tissues of the pancreas, an organ responsible for producing digestive enzymes and regulating blood sugar through hormone secretion. It is one of the most aggressive and deadly forms of cancer due to its typically late diagnosis, rapid progression, and resistance to conventional therapies. The most common type, pancreatic ductal adenocarcinoma ( PDAC ), accounts for over 90% of cases. Risk factors include smoking, chronic pancreatitis, diabetes, obesity, genetic predisposition, and advanced age. Symptoms such as abdominal pain, jaundice , unexplained weight loss, and fatigue often appear only in advanced stages. Current treatment strategies include surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy, with ongoing research focused on early detection, molecular biomarkers, and precision medicine to improve patient outcomes. Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma,...

  Neurogenetic Disorders Neurogenetic disorders are a group of conditions caused by genetic abnormalities that affect the development, structure, or function of the nervous system. These disorders may be inherited or arise from spontaneous genetic mutations and often impact brain function, motor skills, cognition, and behavior. Common neurogenetic disorders include Huntington’s disease, spinal muscular atrophy, Rett syndrome, and various inherited epilepsies. Advances in genomic sequencing , molecular diagnostics , and gene-based therapies have significantly improved early diagnosis, disease management, and the potential for targeted treatments, making neurogenetics a rapidly evolving field in neuroscience and precision medicine. Neurogenetic Disorders, Genetic Neurological Diseases, Inherited Nervous System Disorders, Neurogenetics, Rare Genetic Brain Disorders, Molecular Neurology, Genomic Medicine, Neurodevelopmental Genetics #NeurogeneticDisorders #Neurogenetics #GeneticNeur...

 Host Genetics and Infectious Disease Host genetics plays a critical role in determining individual susceptibility, immune response, and clinical outcomes in infectious diseases. Genetic variations in immune-related genes influence pathogen recognition, disease severity, treatment response, and resistance to infections. Understanding host– pathogen interactions through genetic and genomic studies enables precision medicine, improved diagnostics, targeted therapies, and vaccine development for infectious diseases such as COVID-19, tuberculosis, HIV, malaria, and emerging viral infections. Host genetics, infectious disease genetics, host–pathogen interaction, genetic susceptibility, immune response genes, genomic medicine, disease resistance, pathogen immunity, personalized medicine, infection biology #HostGenetics, #InfectiousDiseases, #HostPathogenInteraction, #GeneticSusceptibility, #Immunogenetics, #GenomicMedicine, #PrecisionMedicine, #DiseaseResistance, #InfectionBiology, #T...

 Inflammatory Bowel Disease Inflammatory Bowel Disease (IBD) refers to a group of chronic disorders that cause inflammation of the digestive tract. The two main types are Crohn’s disease and ulcerative colitis . Symptoms often include abdominal pain, diarrhea (sometimes with blood), weight loss, fatigue, and reduced appetite. IBD is an autoimmune-related condition in which the immune system mistakenly attacks the GI tract . The disease typically goes through periods of flare-ups and remission. While there is no cure, treatment options—such as medications, lifestyle changes, and sometimes surgery—can help manage inflammation and improve quality of life. Inflammatory Bowel Disease, IBD, Crohn’s disease, Ulcerative colitis, Chronic inflammation, Autoimmune disorder, Digestive tract, Gastrointestinal disease, Abdominal pain, Diarrhea, Weight loss, Fatigue, Intestinal inflammation, Flare-ups, Remission, Immune system #InflammatoryBowelDisease #IBD #CrohnsDisease #UlcerativeColitis #Dig...

Spermatogenesis  Spermatogenesis is the process by which the testes produce sperm. It happens in the seminiferous tubules and starts at puberty. Stem cells ( spermatogonia ) divide, form spermatocytes, which undergo meiosis to become spermatids. These spermatids then mature into sperm cells (spermatozoa). The process takes about 2–2.5 months and is controlled by hormones like FSH, LH, and testosterone. Spermatogenesis, Spermatogonia, Spermatocyte, Spermatid, Spermatozoa, Seminiferous tubules, Sertoli cells, Leydig cells, Meiosis, Spermiogenesis, Testosterone, FSH, LH, Germ cells, Male reproductive system #Spermatogenesis #ReproductiveBiology #MaleReproductiveSystem #BiologyNotes #HumanPhysiology #SpermCells #Meiosis #Spermiogenesis #Endocrinology #AnatomyAndPhysiology #MedicalStudies #LifeSciences International Conference on Genetics and Genomics of Diseases  Visit:  genetics-conferences. healthcarek.com Award Nomination:  genetics- conferences.healthcarek.com/ awa...

 Hepatocellular Carcinoma (HCC) Hepatocellular carcinoma (HCC) is the most common primary liver cancer, developing from hepatocytes-the main cells of the liver. It most often occurs in people with chronic liver disease , especially cirrhosis caused by hepatitis B or C infection, long-term alcohol use, or non-alcoholic fatty liver disease (NAFLD/NASH).HCC may not cause symptoms early on, but later can lead to abdominal pain, unintended weight loss, jaundice, or abdominal swelling. Diagnosis typically involves imaging (ultrasound, CT, MRI) and blood tests such as alpha-fetoprotein (AFP).Treatment options depend on the stage and liver function and may include surgical resection, liver transplantation, local ablative therapy, transarterial chemoembolization (TACE), targeted therapies, and immunotherapy. Prevention focuses on vaccination against hepatitis B, treating hepatitis B and C, reducing alcohol use, and managing metabolic risk factors . Hepatocellular carcinoma, Liver cancer, ...

  Cancer Synthetic RNA Cancer Synthetic RNA refers to engineered RNA molecules designed to diagnose, treat, or prevent cancer by precisely targeting tumor-specific genes and cellular pathways. These synthetic RNA constructs—including mRNA , siRNA , miRNA mimics, antisense RNA, and RNA aptamers—can modulate gene expression , silence oncogenes, activate immune responses, or deliver therapeutic instructions to cancer cells. By enabling highly specific molecular interventions, synthetic RNA technologies offer promising advances in personalized oncology, targeted drug delivery, immunotherapy enhancement, and next-generation cancer therapeutics. Cancer synthetic RNA, Synthetic RNA therapy, Cancer mRNA therapeutics, RNA interference in cancer, siRNA cancer treatment, RNA-based oncology, Antisense RNA therapy, RNA nanotechnology, Cancer gene silencing, Precision oncology RNA #CancerSyntheticRNA #SyntheticRNA #RNATherapeutics #CancerTherapy #mRNATherapy #RNAi #siRNATherapy #AntisenseRNA #...