Infection and Gastric Cancer

Comprehensive Analysis of Potential Common Pathogenic Mechanisms for COVID-19 Infection and Gastric Cancer

A growing body of data suggests that the prevalence of COVID-19 pneumonia in patients with stomach cancer is much higher than in the general population. However, these mechanisms are still not fully understood. After a thorough examination of shared differentially expressed genes (DEGs) for gastric cancer (GC) and COVID-19 pneumonia, we performed functional annotation, protein–protein interaction (PPI) networks, module design, and pivot gene identification. qPCR was used to verify the expression of hub genes in GC.

Finally, a pivotal gene transcription factor-gene regulatory network was created and validated. According to functional enrichment analysis, common genes are mainly enriched in biological processes such as extracellular matrix tissue and extracellular structural tissue. Finally, five genes were found to be pivotal genes in the pathogenesis of GC and COVID-19 pneumonia: BGN (biglycan), UBE2C (ubiquitin-conjugating enzymes 2C), SPP1 (secreted phosphoprotein 1), THBS2 (thrombospondin 2), and COL1A1 (type I collagen alpha 1). These shared pathways and pivotal genes could provide new insights for more mechanistic studies.

The prevalence of gastric cancer (GC), particularly in East Asian nations, continues to be a serious worldwide health issue. GC will be the sixth most often diagnosed cancer and the third-leading cause of cancer-related deaths worldwide in 2020, with more than 1,089,103 (5.6%) diagnoses and more than 768,000 (7.7%) fatalities worldwide. The regions with the highest incidence of GC are Northeast Asia, Central and South America, and Eastern Europe. Although H. pylori infection, smoking, alcohol consumption, a high-salt diet, and physical inactivity are now widely acknowledged as independent risk factors for GC, the pathophysiology of the disease is still unknown for the majority of patients.

Investigating the shared transcriptional signature between GC and COVID-19 pneumonia may reveal fresh information about the shared etiology of these two illnesses. We wanted to find important genes connected to the etiology of GC concomitant with COVID-19 pneumonia in this investigation. We analyzed the dataset downloaded from the GEO database. Common differentially expressed genes (DEGs) and their roles in COVID-19 pneumonia and GC were discovered using integrated bioinformatics and enrichment analysis. 

The STRING (Search Tool for Retrieving Interacting Gene) database and Cytoscape software (version 3.10.1) were also used to evaluate gene modules and find pivotal genes, which was followed by the confirmation of the pivotal genes. Finally, we selected 15 crucial essential genes, confirmed them, and further developed a TF-gene regulatory network for these genes. It is anticipated that the key genes between COVID-19 pneumonia and GC discovered in this work may reveal fresh details about the biological underpinnings of these two disorders.

gastric cancer, stomach cancer, adenocarcinoma, H. pylori infection, gastric tumors, cancer staging, chemotherapy, radiation therapy, targeted therapy, immunotherapy, gastrectomy, early detection, gastric biopsy, tumor markers, cancer prognosis, gastric ulcer, cancer metastasis, gastric mucosa, palliative care, oncology research

#GastricCancer, #StomachCancer, #CancerAwareness, #Oncology, #HelicobacterPylori, #CancerResearch, #CancerTreatment, #EarlyDetection, #Chemotherapy, #RadiationTherapy, #TargetedTherapy, #Immunotherapy, #Gastrectomy, #CancerSurvivor, #CancerCare, #TumorBiology, #PalliativeCare, #Gastroenterology, #CancerSupport, #MedicalResearch

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