Skip to main content

Infection and Gastric Cancer

Comprehensive Analysis of Potential Common Pathogenic Mechanisms for COVID-19 Infection and Gastric Cancer


A growing body of data suggests that the prevalence of COVID-19 pneumonia in patients with stomach cancer is much higher than in the general population. However, these mechanisms are still not fully understood. After a thorough examination of shared differentially expressed genes (DEGs) for gastric cancer (GC) and COVID-19 pneumonia, we performed functional annotation, protein–protein interaction (PPI) networks, module design, and pivot gene identification. qPCR was used to verify the expression of hub genes in GC.

Finally, a pivotal gene transcription factor-gene regulatory network was created and validated. According to functional enrichment analysis, common genes are mainly enriched in biological processes such as extracellular matrix tissue and extracellular structural tissue. Finally, five genes were found to be pivotal genes in the pathogenesis of GC and COVID-19 pneumonia: BGN (biglycan), UBE2C (ubiquitin-conjugating enzymes 2C), SPP1 (secreted phosphoprotein 1), THBS2 (thrombospondin 2), and COL1A1 (type I collagen alpha 1). These shared pathways and pivotal genes could provide new insights for more mechanistic studies.

The prevalence of gastric cancer (GC), particularly in East Asian nations, continues to be a serious worldwide health issue. GC will be the sixth most often diagnosed cancer and the third-leading cause of cancer-related deaths worldwide in 2020, with more than 1,089,103 (5.6%) diagnoses and more than 768,000 (7.7%) fatalities worldwide. The regions with the highest incidence of GC are Northeast Asia, Central and South America, and Eastern Europe. Although H. pylori infection, smoking, alcohol consumption, a high-salt diet, and physical inactivity are now widely acknowledged as independent risk factors for GC, the pathophysiology of the disease is still unknown for the majority of patients.

Investigating the shared transcriptional signature between GC and COVID-19 pneumonia may reveal fresh information about the shared etiology of these two illnesses. We wanted to find important genes connected to the etiology of GC concomitant with COVID-19 pneumonia in this investigation. We analyzed the dataset downloaded from the GEO database. Common differentially expressed genes (DEGs) and their roles in COVID-19 pneumonia and GC were discovered using integrated bioinformatics and enrichment analysis. 

The STRING (Search Tool for Retrieving Interacting Gene) database and Cytoscape software (version 3.10.1) were also used to evaluate gene modules and find pivotal genes, which was followed by the confirmation of the pivotal genes. Finally, we selected 15 crucial essential genes, confirmed them, and further developed a TF-gene regulatory network for these genes. It is anticipated that the key genes between COVID-19 pneumonia and GC discovered in this work may reveal fresh details about the biological underpinnings of these two disorders.

gastric cancer, stomach cancer, adenocarcinoma, H. pylori infection, gastric tumors, cancer staging, chemotherapy, radiation therapy, targeted therapy, immunotherapy, gastrectomy, early detection, gastric biopsy, tumor markers, cancer prognosis, gastric ulcer, cancer metastasis, gastric mucosa, palliative care, oncology research

#GastricCancer, #StomachCancer, #CancerAwareness, #Oncology, #HelicobacterPylori, #CancerResearch, #CancerTreatment, #EarlyDetection, #Chemotherapy, #RadiationTherapy, #TargetedTherapy, #Immunotherapy, #Gastrectomy, #CancerSurvivor, #CancerCare, #TumorBiology, #PalliativeCare, #Gastroenterology, #CancerSupport, #MedicalResearch

International Conference on Genetics and Genomics of Diseases

Visit: genetics-conferences.healthcarek.com

Award Nomination: genetics-conferences.healthcarek.com/award-nomination/?ecategory=Awards&rcategory=Awardee

Award registration: genetics-conferences.healthcarek.com/award-registration/

For Enquiries: contact@healthcarek.com

Get Connected Here
---------------------------------
---------------------------------
in.pinterest.com/Dorita0211
twitter.com/Dorita_02_11_
facebook.com/profile.php?id=61555903296992
instagram.com/p/C4ukfcOsK36
genetics-awards.blogspot.com/
youtube.com/@GeneticsHealthcare

Comments

Post a Comment

Popular posts from this blog

Fruitful innovation

Fruitful innovation: Transforming watermelon genetics with advanced base editors The development of new adenine base editors (ABE) and adenine-to-thymine/ guanine base editors (AKBE) is transforming watermelon genetic engineering. These innovative tools enable precise A:T-to-G and A:T-to-T base substitutions, allowing for targeted genetic modifications. The research highlights the efficiency of these editors in generating specific mutations, such as a flowerless phenotype in ClFT (Y84H) mutant plants. This advancement not only enhances the understanding of gene function but also significantly improves molecular breeding, paving the way for more efficient watermelon crop improvement. Traditional breeding methods for watermelon often face challenges in achieving desired genetic traits efficiently and accurately. While CRISPR/Cas9 has provided a powerful tool for genome editing, its precision and scope are sometimes limited. These limitations highlight the need for more advanced gene-e...
Post a Comment
Read more

Genetic factors with clinical trial stoppage

Genetic factors associated with reasons for clinical trial stoppage Many drug discovery projects are started but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the free-text reasons for 28,561 clinical trials that stopped before their endpoints were met. We then evaluated these classes in light of the underlying evidence for the therapeutic hypothesis and target properties. We found that trials are more likely to stop because of a lack of efficacy in the absence of strong genetic evidence from human populations or genetically modified animal models. Furthermore, certain trials are more likely to stop for safety reasons if the drug target gene is highly constrained in human populations and if the gene is broadly expressed across tissues. These results support the growing use of human genetics to ...
Post a Comment
Read more

Genetics study on COVID-19

Large genetic study on severe COVID-19 Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal " Human Genetics and Genomics Advances ". Even though the number of severe cases following infection with the SARS-CoV-...
Post a Comment
Read more