February 28, 2025

Liver Disease for Precision Medicine

Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine



Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous disease regarding its pathophysiology and clinical outcomes. Two novel studies suggest that different clusters of people with MASLD exist, explaining part of this heterogeneity. These findings and future research applying data dimensionality reduction approaches might be beneficial for implementing precision medicine in MASLD.

The basic, translational and clinical content in Nature Reviews Gastroenterology & Hepatology is written by internationally renowned basic and clinical academics and researchers and targeted towards readers in the biological and medical sciences, from postgraduate level upwards. While intended to be read by practising doctors, researchers and academics within a specialty, we aim to make all our articles accessible to readers working in any biological or medical discipline.

In-depth Reviews present authoritative, up-to-date information on a topic, placing it in the context of a field's history and development. Consensus Statements provide evidence-based or eminence-based recommendations and present a balanced review put together by a task force of experts. Topical discussion and opinions are proffered in Perspectives, Comment and News & Views articles, and in the Research Highlights section we filter primary research from a range of specialty and general medical and scientific journals.

gene mutation, genomic sequencing, rare disorders, single nucleotide polymorphism, epigenetic alterations, copy number variations, chromosomal abnormalities, mitochondrial disorders, autosomal inheritance, recessive traits, precision medicine, CRISPR technology, genetic counseling, exome analysis, hereditary syndromes, phenotypic variability, non-coding DNA mutations, gene therapy breakthroughs

#Genetics #RareDiseases #GeneMutation #GenomicSequencing #PrecisionMedicine #CRISPR #GeneTherapy #GeneticCounseling #HereditarySyndromes #ChromosomalAbnormalities #Epigenetics #ExomeAnalysis #PhenotypicVariability #MolecularDiagnostics #RareSyndromes #InheritedDisorders #MitochondrialDiseases #CNVs #Transcriptomics #GeneticHealth

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Liver Disease for Precision Medicine

Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine Metabolic dysfunction-associated steatotic liver...