Skip to main content

Genetical News

Why some shorter parents have surprisingly tall kids ?


Height is often considered a straightforward inheritance from parents, but sometimes, shorter parents end up with unexpectedly tall children. This phenomenon may seem surprising at first, but it offers a fascinating glimpse into the complexities of genetics and ancestral traits.

This was highlighted by content creator Chirag Barjatya in a reel posted on Instagram, where he mentions, “You may have noticed that many celebrities who are not very tall have children who are much taller. For example, Saif Ali Khan’s children, Sachin Tendulkar’s son, Ronit Roy’s son, or Shah Rukh Khan’s children. We often assume that our height solely depends on our parents’ genetics, but that’s not entirely true. (sic).”

Factors like genetic recombination, environmental influences, and even recessive traits passed down through generations play a significant role in determining a child’s height. But how exactly do these elements combine to produce taller offspring from shorter parents? Let’s delve deeper with insights from an expert.

How does genetic recombination lead to a child being significantly taller than their parents?

“Genetic recombination is a critical process during the formation of reproductive cells (sperm and egg), where genetic material is shuffled and rearranged,” explains Dr Vinutha. This can result in unique combinations of height-related genes that may not have been expressed in the parents, leading to a taller child.

Height is a polygenic trait influenced by multiple genes. Recombination can consolidate favourable height-related genes, sometimes from ancestors, resulting in a noticeable height increase in offspring. Additionally, random genetic variations during recombination can activate latent genes that promote growth, according to studies in Nature Genetics.

Role ancestry plays in influencing traits like height

Ancestry significantly impacts height through genetic diversity across populations. “Scandinavian populations, for instance, tend to have taller average heights, possibly due to evolutionary adaptations favoring robust physical builds,” says Dr Vinutha. On the other hand, populations from resource-scarce regions often evolved shorter statures for metabolic efficiency.

Recessive genes for height can indeed skip generations. “If a grandparent carried recessive genes for tall stature that weren’t expressed in the parents, these genes might combine in the child, leading to unexpected height.” Similarly, mixed ancestry may produce traits that deviate from immediate family patterns.



Environmental or lifestyle factors that could amplify genetic predispositions for height

While genetics are primary, Dr Vinutha stresses the importance of the environment: “Adequate nutrition, hormonal health, physical activity, quality sleep, and avoiding growth inhibitors like smoking or alcohol are essential for reaching genetic height potential.”Nutrition: A diet rich in protein, calcium, and vitamins like D and C supports bone growth. Malnutrition during growth periods can stunt height.
Hormonal health: Growth hormone (GH) is crucial; disruptions like hypothyroidism or chronic stress can hinder growth.

Physical activity: Sports like swimming or basketball stimulate GH release and improve bone density.
Sleep: Most GH is released during deep sleep, making consistent rest critical.

Absence of Growth Inhibitors: Avoiding factors like smoking, alcohol, or chronic illnesses during adolescence can prevent the suppression of genetic height potential.

Could advancements in genetic studies one day allow parents to predict or influence their child’s height more accurately?

Dr Vinutha points to emerging technologies like polygenic risk scores (PRS), which analyze the cumulative effect of multiple genes on traits like height. “Studies in Cell show PRS can predict adult height with reasonable accuracy when combined with environmental data.”

Gene-editing tools like CRISPR could theoretically modify height-related genes, but this remains experimental and raises ethical concerns. “Epigenetics also offers hope, as optimising a child’s nutrition and health can influence the expression of growth-promoting genes,” she adds.

genetic diversity, epigenetics, inheritance, genes, recessive traits, genetic recombination, polygenic traits, environmental factors, height variability, epigenetic modifications, nutrition, exercise, hormonal health, growth spurts, puberty, genetic research, height predictors, heritability, height potential, surprising outcomes.

#Genetics #HeightInheritance #Epigenetics #GrowthSpurt #ChildHeight #HeightPotential #NutritionMatters #EnvironmentalFactors #GeneticResearch #HeightHeritability #PolygenicTraits #ParentalGenes #TallKids #UnexpectedGrowth #EpigeneticInfluence #RecessiveGenes #GeneticDiversity #HeightPredictors #SurprisingOutcomes #Heritability

Comments

Popular posts from this blog

Fruitful innovation

Fruitful innovation: Transforming watermelon genetics with advanced base editors The development of new adenine base editors (ABE) and adenine-to-thymine/ guanine base editors (AKBE) is transforming watermelon genetic engineering. These innovative tools enable precise A:T-to-G and A:T-to-T base substitutions, allowing for targeted genetic modifications. The research highlights the efficiency of these editors in generating specific mutations, such as a flowerless phenotype in ClFT (Y84H) mutant plants. This advancement not only enhances the understanding of gene function but also significantly improves molecular breeding, paving the way for more efficient watermelon crop improvement. Traditional breeding methods for watermelon often face challenges in achieving desired genetic traits efficiently and accurately. While CRISPR/Cas9 has provided a powerful tool for genome editing, its precision and scope are sometimes limited. These limitations highlight the need for more advanced gene-e...

Genetic factors with clinical trial stoppage

Genetic factors associated with reasons for clinical trial stoppage Many drug discovery projects are started but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the free-text reasons for 28,561 clinical trials that stopped before their endpoints were met. We then evaluated these classes in light of the underlying evidence for the therapeutic hypothesis and target properties. We found that trials are more likely to stop because of a lack of efficacy in the absence of strong genetic evidence from human populations or genetically modified animal models. Furthermore, certain trials are more likely to stop for safety reasons if the drug target gene is highly constrained in human populations and if the gene is broadly expressed across tissues. These results support the growing use of human genetics to ...

Genetics study on COVID-19

Large genetic study on severe COVID-19 Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal " Human Genetics and Genomics Advances ". Even though the number of severe cases following infection with the SARS-CoV-...