Skip to main content

Reduce Genetic Risk of High Cholesterol

Fish Oil Supplementation May Reduce Genetic Risk of High Cholesterol



Fish oil and other omega-3 supplements may reduce the genetic risk of high total cholesterol and low-density lipoprotein (LDL) cholesterol, according to data published in The American Journal of Clinical Nutrition. The authors’ findings indicate that individuals who reported regular supplementation of fish oil had lower blood lipid levels, especially for total cholesterol, LDL cholesterol, and triglycerides.

Many patients turn to fish oil supplements, and they are frequently suggested by pharmacists as a method for increasing omega-3 fatty acid intake. Studies indicate that omega-3s have anti-inflammatory properties that may provide relief from mild inflammation or joint pain, and fish oil supplementation, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may protect the heart by reducing triglyceride concentrations. It is important to know which patients may benefit from omega-3 supplements the most, the supplements’ proper dosage, and the benefits that can be expected.Pharmacists can be essential sources of education for patients, offering them guidance on safe use, proper dosage, and the reasonings behind these recommendations to ensure positive outcomes.

The authors examined whether fish oil supplementation modifies the association between genetically predicted and observed concentrations of total cholesterol, LDL cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. Using UK Biobank, they collected and assessed complete genetic and phenotypic data from 441,985 individuals aged 37 to 73. Participants provided blood samples, as well as sociodemographic, lifestyle, and medical records information via questionnaires at baseline.

Fish oil supplementation was determined through a touchscreen questionnaire that asked about consumption of specific supplements; however, it did not collect the dose, frequency, or duration of supplementation. The study included the primary outcomes of 4 serum lipid parameters including total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. Using multivariable linear regression models, the authors assessed the modifying impacts of fish oil supplementation on the associations between the polygenic scores of the 4 lipids and their observed concentrations. These analyses were performed separately for each lipid across 4 ancestry groups: European, African, Central/South Asian, and East Asian.

According to the data, 31.8% of the participants reported habitual use of fish oil, of which 56% were female with a mean age of 59 years. Participants who consumed fish oil were more likely to be older, female, current alcohol drinkers, statin users, engaged in high physical activity, and have higher concentrations of total cholesterol, LDL cholesterol, and HDL cholesterol. Among other ancestry groups, 2,289 (34.8%) African, 1,942 (22.5%) Central/South Asian, and 845 (31.6%) East Asian participants used fish oil.

Overall, the data indicated that fish oil supplementation weakened the association between genetically predicted and observed circulating concentrations of total cholesterol, LDL cholesterol, and triglycerides while strengthening the corresponding association for HDL cholesterol. This suggests the ability of fish oil to lower specific lipid levels, thereby reducing their influence on genetic risk, as well as enhance the body’s ability to maintain higher HDL levels.

“Our study shows that considering lifestyles will improve genetic prediction,” Kaixiong Ye, BS, PhD, corresponding author of the study and an assistant professor of genetics in Franklin College of Arts and Sciences at the University of Georgia in Athens, said in an interview with UGA Today. “Our findings also support that fish oil supplements may counteract the genetic predisposition to high cholesterol.”

The study had some potential limitations, such as unreliable self-reported fish oil intake, lack of dosage information, and the inability to evaluate the effects of fish oil for an extended duration of use. Studies with larger sample sizes and accurate dose information are needed to further expand the findings. However, the initial data supports the hypothesis that genetic effects on blood lipid concentrations could be modified by habitual fish oil supplementation.

genetic risk, high cholesterol, cardiovascular disease, cholesterol levels, lifestyle modifications, healthy diet, saturated fats, physical activity, smoking cessation, weight management, omega-3 fatty acids, cholesterol control, regular screenings, family history, statins, cholesterol medication, heart health, prevention, dietary changes, lipid levels,

#GeneticRisk, #HighCholesterol, #CardiovascularHealth, #CholesterolLevels, #HealthyLifestyle, #DietAndExercise, #SaturatedFats, #PhysicalActivity, #SmokingCessation, #WeightManagement, #Omega3FattyAcids, #CholesterolControl, #RegularScreenings, #FamilyHistory, #Statins, #HeartHealth, #CholesterolPrevention, #DietaryChanges, #LipidLevels, #CholesterolManagement

International Conference on Genetics and Genomics of Diseases 




For Enquiries: genetics@healthcarek.com 

Get Connected Here 
--------------------------------- 
--------------------------------- 
facebook.com/profile.php?id=61555903296992 
tumblr.com/blog/dorita0211 

Comments

Popular posts from this blog

Fruitful innovation

Fruitful innovation: Transforming watermelon genetics with advanced base editors The development of new adenine base editors (ABE) and adenine-to-thymine/ guanine base editors (AKBE) is transforming watermelon genetic engineering. These innovative tools enable precise A:T-to-G and A:T-to-T base substitutions, allowing for targeted genetic modifications. The research highlights the efficiency of these editors in generating specific mutations, such as a flowerless phenotype in ClFT (Y84H) mutant plants. This advancement not only enhances the understanding of gene function but also significantly improves molecular breeding, paving the way for more efficient watermelon crop improvement. Traditional breeding methods for watermelon often face challenges in achieving desired genetic traits efficiently and accurately. While CRISPR/Cas9 has provided a powerful tool for genome editing, its precision and scope are sometimes limited. These limitations highlight the need for more advanced gene-e...

Genetic factors with clinical trial stoppage

Genetic factors associated with reasons for clinical trial stoppage Many drug discovery projects are started but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the free-text reasons for 28,561 clinical trials that stopped before their endpoints were met. We then evaluated these classes in light of the underlying evidence for the therapeutic hypothesis and target properties. We found that trials are more likely to stop because of a lack of efficacy in the absence of strong genetic evidence from human populations or genetically modified animal models. Furthermore, certain trials are more likely to stop for safety reasons if the drug target gene is highly constrained in human populations and if the gene is broadly expressed across tissues. These results support the growing use of human genetics to ...

Genetics study on COVID-19

Large genetic study on severe COVID-19 Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal " Human Genetics and Genomics Advances ". Even though the number of severe cases following infection with the SARS-CoV-...