Skip to main content

Alzheimer Disease

Gaining Greater Insights on the Role of Genetics and Microglia and Alzheimer Disease: Gareth Howell, PhD


"By embracing genetic heterogeneity in mouse models, we can better replicate the complexity of human Alzheimer disease and improve our understanding of its mechanisms."


For Alzheimer disease (AD) and also many other neurodegenerative disorders, familial aggregation was already recognized as a salient feature decades before any of the underlying molecular genetic and biochemical properties were known. Over the years, genome-wide genotyping and second-generation sequencing technologies have drastically changed the approaches used to study these disorders. In addition, there is growing evidence to suggest that underlying genetics can significantly modify response to development of amyloid and tau pathology with age.

At the 2024 Alzheimer’s Association International Conference (AAIC), held July 28-August 1, in Philadelphia, Pennsylvania, researchers from the Jackson Laboratory in Florida presented data looking at how genetics can impact microglia function, and how these differences related to AD pathology, and ultimately, cognitive decline. To achieve this, the study authors introduced humanized amyloid-ß (with and without driver mutations) and MAPT sequences in 2 mouse strains, C57BL/6J (B6) and WSB/EiJ (WSB).

Although the analyses are ongoing, results showed that B6 and WSB mice that carried humanized amyloid-ß without mutations did not exhibit significant amyloid pathology at 10 months. In contrast, B6 and WSB mice that carried the Swedish-Arctic-Austrian mutations did show significant parenchymal deposition starting at 6 months of age, and WSB exhibited mature cerebral amyloid angiopathy.

Senior author Gareth Howell, PhD, believes there is benefits to utilizing diverse mouse models to study AD. During the meeting, Howell, a professor of neurology and the Diana Davis Spencer Foundation Chair at the Jackson Laboratory, sat down to discuss the research and its significance. He provided commentary on the growing knowledge of microglia and its impact on AD, and how genetic variations in microglia-linked genes increase disease susceptibility.

rexinoids, gene expression, glioblastoma, retinoid X receptors, RXRs, proliferation, apoptosis, differentiation, brain tumor, prognosis, molecular mechanisms, therapeutic strategies, protein-protein interactions, yeast two-hybrid system, functional networks, cancer biology, targeted therapy, human glioblastoma cells, cellular processes, novel therapies,

#Rexinoids, #GeneExpression, #Glioblastoma, #RetinoidXReceptors, #RXRs, #Proliferation, #Apoptosis, #Differentiation, #BrainTumor, #Prognosis, #MolecularMechanisms, #TherapeuticStrategies, #ProteinProteinInteractions, #YeastTwoHybridSystem, #FunctionalNetworks, #CancerBiology, #TargetedTherapy, #HumanGlioblastomaCells, #CellularProcesses, #NovelTherapies

International Conference on Genetics and Genomics of Diseases

Visit: genetics-conferences.healthcarek.com

Award Nomination: x-i.me/gennom1
Award registration: x-i.me/genreg2
Member Nomination: x-i.me/genmember
Member Registration: x-i.me/genreg1
For Enquiries: genetics@healthcarek.com


Get Connected Here
---------------------------------
---------------------------------

Pinterest: x-i.me/genpt
Twitter: x-i.me/gentw
Facebook: x-i.me/genfb
Instagram: x-i.me/genin
Youtube: x-i.me/genyt

Comments

Post a Comment

Popular posts from this blog

Genetics role in ovarian cancer

The Medical Minute: Genetics play big role in ovarian cancer In 2024, about 19,680 women in the United States will receive a new diagnosis of ovarian cancer and 12,740 women will die from the disease, said Dr. Shaina Bruce , a gynecologic oncologist at Penn State Cancer Institute . The median age of all patients who develop ovarian cancer is 63. Historically, women at increased risk for ovarian cancer are recommended to have their fallopian tubes and ovaries removed when they have completed having children. Taking that step to protect themselves comes at a heavy price ― surgical menopause. But Bruce said medical science is catching up with ovarian cancer. Studies could lead to new methods for preventative care and the surgery needed to lower risk may be easier than it once was. Below, during Gynecologic Cancer Awareness Month, Bruce discusses the disease and why acting to reduce your risk is worth it. What’s the connection between heredity and ovarian cancer? About 25% of all cases of ...
Post a Comment
Read more

Migration in Population Genetics

  Migration in Population Genetics Migration in population genetics refers to the movement of individuals-and therefore their genes -between different populations of the same species. This gene flow alters allele frequencies, increasing genetic diversity within populations while reducing genetic differences between them. Migration can counteract the effects of genetic drift and inbreeding , introduce new alleles , and influence evolutionary processes such as adaptation and natural selection. The rate, direction, and scale of migration play a crucial role in shaping population structure, evolutionary potential, and long-term species survival, especially in fragmented habitats or changing environments. Migration, Population Genetics, Gene Flow, Allele Frequency, Genetic Diversity, Evolution, Genetic Variation, Population Structure, Adaptation, Biodiversity #PopulationGenetics #Migration #GeneFlow #GeneticDiversity #EvolutionaryBiology #AlleleFrequency #NaturalSelection #GeneticD...
Post a Comment
Read more

Chromosomal Abnormalities

  Chromosomal Abnormalities Chromosome abnormalities refer to structural or numerical changes in chromosomes that can disrupt normal genetic function, leading to developmental disorders, congenital abnormalities, and various genetic diseases. These abnormalities may arise from errors in cell division, such as nondisjunction or chromosomal breakage, resulting in conditions like Down syndrome , Turner syndrome, Klinefelter syndrome , and various deletion or duplication syndromes. Understanding chromosome abnormalities is essential for genetic counseling, prenatal diagnosis, disease risk assessment, and research in cytogenetics and molecular genetics. Chromosome abnormalities, chromosomal disorders, chromosomal mutations, aneuploidy, structural chromosome abnormalities, nondisjunction, deletion syndrome, duplication syndrome , translocation, inversion, cytogenetics, karyotyping, prenatal diagnosis , genetic testing, genomic instability, Down syndrome, Turner syndrome, Klinefelter syn...
Post a Comment
Read more