Skip to main content

Immunogenetics

Immunogenetics:

Immunogenetics is the study of the genetic basis of the immune response. It combines aspects of immunology and genetics to understand how genetic variations affect the immune system's functioning and its response to pathogens.

Here are some key points about immunogenetics:

1. Major Histocompatibility Complex (MHC): MHC genes play a crucial role in the immune system by presenting peptide fragments to T cells, which then initiate an immune response. Variability in MHC genes influences individual susceptibility to infectious diseases, autoimmune diseases, and transplant rejection. 

2. Autoimmune Diseases: Genetic predispositions can lead to autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. Studies in immunogenetics help identify specific genes and genetic mutations associated with these conditions.

3. Allergies and Asthma: Genetic factors contribute to the development of allergic reactions and asthma. Research in this field aims to understand the genetic mechanisms underlying these conditions to improve diagnosis and treatment.

4. Infectious Diseases: Host genetic factors can influence susceptibility to infectious diseases. Immunogenetics studies help identify genetic variants that affect how individuals respond to infections, which can guide the development of personalized medicine approaches.

5. Cancer Immunotherapy: Understanding the genetic makeup of both the tumor and the patient’s immune system can improve the effectiveness of immunotherapies. Genetic profiling can help predict which patients are likely to respond to specific treatments.

6. Transplantation: Genetic matching of donor and recipient MHC (also known as HLA in humans) is crucial for the success of organ and tissue transplants. Immunogenetics research helps improve matching techniques and reduces the risk of transplant rejection.

7. Vaccines: Genetic factors can influence individual responses to vaccines. Research in immunogenetics aims to develop more effective vaccines and personalized vaccination strategies based on genetic profiles.

immune response, MHC, autoimmune diseases, allergies, asthma, infectious diseases, cancer immunotherapy, transplantation, vaccines, genetic predisposition, T cells, B cells, HLA, antigen presentation, genetic susceptibility, personalized medicine, immune system, genetic mutations, host-pathogen interactions

#Immunogenetics, #GeneticVariations, #ImmuneResponse, #MHC, #AutoimmuneDiseases, #Allergies, #Asthma, #InfectiousDiseases, #CancerImmunotherapy, #Transplantation, #Vaccines, #GeneticPredisposition, #TCells, #BCells, #HLA, #AntigenPresentation, #GeneticSusceptibility, #PersonalizedMedicine, #ImmuneSystem, #GeneticMutations, #HostPathogenInteractions

Comments

Post a Comment

Popular posts from this blog

Fruitful innovation

Fruitful innovation: Transforming watermelon genetics with advanced base editors The development of new adenine base editors (ABE) and adenine-to-thymine/ guanine base editors (AKBE) is transforming watermelon genetic engineering. These innovative tools enable precise A:T-to-G and A:T-to-T base substitutions, allowing for targeted genetic modifications. The research highlights the efficiency of these editors in generating specific mutations, such as a flowerless phenotype in ClFT (Y84H) mutant plants. This advancement not only enhances the understanding of gene function but also significantly improves molecular breeding, paving the way for more efficient watermelon crop improvement. Traditional breeding methods for watermelon often face challenges in achieving desired genetic traits efficiently and accurately. While CRISPR/Cas9 has provided a powerful tool for genome editing, its precision and scope are sometimes limited. These limitations highlight the need for more advanced gene-e...
Post a Comment
Read more

Genetic factors with clinical trial stoppage

Genetic factors associated with reasons for clinical trial stoppage Many drug discovery projects are started but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the free-text reasons for 28,561 clinical trials that stopped before their endpoints were met. We then evaluated these classes in light of the underlying evidence for the therapeutic hypothesis and target properties. We found that trials are more likely to stop because of a lack of efficacy in the absence of strong genetic evidence from human populations or genetically modified animal models. Furthermore, certain trials are more likely to stop for safety reasons if the drug target gene is highly constrained in human populations and if the gene is broadly expressed across tissues. These results support the growing use of human genetics to ...
Post a Comment
Read more

Genetics study on COVID-19

Large genetic study on severe COVID-19 Bonn researchers confirm three other genes for increased risk in addition to the known TLR7 gene Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal " Human Genetics and Genomics Advances ". Even though the number of severe cases following infection with the SARS-CoV-...
Post a Comment
Read more