International Genetics and Genomics of Diseases

Double-Peteled Phenotype The double-petaled phenotype is a floral morphological trait in which flowers develop more than the typical number of petals , often due to the transformation of reproductive organs (such as stamens) into petal-like structures. This phenotype is widely observed in ornamental plants and is highly valued for its enhanced aesthetic appeal. At the genetic level, double-petaling is commonly associated with alterations in floral organ identity genes , particularly MADS-box transcription factors that regulate flower development. Epigenetic modifications , gene mutations , and regulatory pathway interactions can all contribute to this trait . Beyond ornamentation, the double-petaled phenotype serves as an important model for studying floral evolution, developmental genetics , and plant breeding strategies . Double-petaled phenotype, Floral morphology, Flower development, Petal number variation, MADS-box genes, Floral organ identity, Plant developmental genetics, O...

 Polymeric Gene Interaction Polymeric gene interaction refers to the combined effect of two or more genes that contribute additively or synergistically to the expression of a single quantitative trait. Unlike epistasis, where one gene masks the effect of another, polymeric genes independently influence the phenotype , and their cumulative action determines trait intensity. This type of interaction is commonly observed in complex traits such as height, skin color, yield potential, disease susceptibility, and stress tolerance. Polymeric gene interactions play a crucial role in quantitative genetics , population genetics , plant and animal breeding , and human disease research , helping scientists understand multifactorial inheritance patterns and polygenic disorders . Polymeric gene interaction, Polygenic inheritance, Quantitative traits, Additive gene effect, Gene–gene interaction, Multifactorial inheritance, Complex traits, Genetic architecture, Phenotypic variation, Quantitative ...

 Small Cell Lung Cancer Small Cell Lung Cancer (SCLC) is an aggressive and fast-growing form of lung cancer that originates from n euroendocrine cells in the lungs. It accounts for approximately 10–15% of all lung cancer cases and is strongly associated with cigarette smoking. SCLC is characterized by rapid tumor growth, early metastasis, and high sensitivity to chemotherapy  and  radiotherapy . However, despite initial responsiveness to treatment, recurrence is common, and long-term survival rates remain low. Advances in molecular biology , immunotherapy , and targeted treatment strategies are improving understanding of SCLC pathogenesis and opening new avenues for personalized cancer care. Small Cell Lung Cancer, SCLC, lung cancer, neuroendocrine carcinoma, smoking-related cancer, aggressive cancer, lung tumor, chemotherapy, radiotherapy, immunotherapy, cancer metastasis, oncology, pulmonary oncology, cancer biology #SmallCellLungCancer #SCLC #LungCancer #Neuroendocri...

 Behaviour and the Interaction of Heredity Behaviour and the interaction of heredity explore how genetic inheritance and environmental influences jointly shape human actions, personality, cognition, and emotional responses. Heredity provides the biological foundation through genes that influence traits such as temperament, intelligence, and susceptibility to mental or neurological disorders. Environmental factors—including upbringing, education, culture, and life experiences—interact dynamically with genetic predispositions to influence behavioral outcomes. Modern research in behavioral genetics , psychology , neuroscience , and epigenetics highlights that behavior is not determined by genes alone but emerges from complex gene–environment interactions across the lifespan. Understanding this interplay is essential for advancing mental health research, personalized medicine, and behavioral interventions. Behavioural Genetics, Heredity, Gene–Environment Interaction, Human Behavi...

 Critical Role of Nucleic Acids Nucleic acids are fundamental biomolecules that play a critical role in the storage, transmission, and expression of genetic information in all living organisms. Deoxyribonucleic acid ( DNA ) carries hereditary instructions that determine cellular structure, function, and development, while ribonucleic acid ( RNA ) is essential for translating this genetic code into functional proteins. Together, nucleic acids regulate vital biological processes such as cell division, growth, metabolism, and adaptation. They are central to molecular biology , genetics , and genomics , enabling processes like gene regulation , mutation , evolution, and inheritance. Understanding the critical role of nucleic acids has driven major advances in medical research, biotechnology, precision medicine, and the diagnosis and treatment of genetic and infectious diseases. Nucleic Acids, DNA Structure, RNA Function, Genetic Information, Gene Expression, Molecular Biology, Gen...

 Neurodegeneration Disorders Neurodegenerative disorders are a group of progressive diseases characterized by the gradual loss of structure and function of neurons in the brain and spinal cord . These conditions lead to cognitive, motor, and behavioral impairments that worsen over time and significantly affect quality of life. Common neurodegenerative disorders include Alzheimer’s disease , Parkinson’s disease , Huntington’s disease , amyotrophic lateral sclerosis (ALS), and multiple system atrophy. Their development is influenced by genetic factors , aging, protein misfolding, mitochondrial dysfunction, oxidative stress, and neuroinflammation. Although most neurodegenerative disorders have no definitive cure, advances in genetics , biomarkers, neuroimaging, and precision medicine are improving early diagnosis, disease monitoring, and the development of targeted therapies. Neurodegenerative Disorders, Neurodegeneration, Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disea...