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Genetic Dissection

Genetic Dissection of Yield-Related Traits in a Set of Maize Recombinant Inbred Lines Under Multiple Environments Agronomic advancements have led to significant increases in maize yield per hectare in Northeast China, primarily through improved density tolerance. However, the genetic mechanism underlying grain yield responses to density stress remains poorly understood. Here, a population of 193 recombinant inbred lines (RILs) derived from the cross between ZM058 and PH1219 was employed to identify quantitative trait loci (QTLs) under two planting densities across three locations over two years. Six yield-related traits were investigated: ear tip-barrenness length (BEL), cob diameter (CD), ear diameter (ED), ear length (EL), kernel number per row (KNR), and kernel row number (KRN).  These traits exhibited distinct and divergent responses to density stress, with the values of CD, ED, EL, KNR and KRN decreasing as planting density increased, except for BEL. A total of 81 QTLs were id...
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Genetic deletion in cerebellum

Genetic deletion in cerebellum impedes hemisphere formation, study finds The cerebellum, a brain region located at the back of the head that has long been known to support the coordination of muscle movements, has recently also been implicated in more sophisticated mental functions. Purkinje cells are the only neurons located in the cerebellum that integrate information in the cerebellar cortex and send it to other parts of the nervous system. Purkinje cells are large and highly branched nerve cells that can have different functions. While many past studies have explored the roles of these cells, the neural and genetic processes shaping their diversity have not yet been fully elucidated. Researchers at the University of Connecticut School of Medicine recently carried out a study aimed at exploring the possible role of the FOXP genes, a family of genes known to contribute to switching other genes "on and off," in shaping Purkinje cell populations and the formation of circuits...

Treating Genetic Diseases

New generation of CRISPR shows safer path to treating genetic diseases A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like Sickle Cell, while also proving beyond doubt that chemical tags on DNA - often thought to be little more than genetic cobwebs - actively silence genes. For decades, scientists have debated whether methyl groups - small chemical clusters that accumulate on DNA - are simply detritus that accumulates in the genome where genes are turned off, or the actual cause of gene repression. But now researchers at UNSW, working with colleagues in the US at the St Jude Children's Research Hospital (Memphis), have shown in a paper published recently in Nature Communications, that removing these tags can switch genes back on, confirming that methylation is not just correlated with silencing, but directly responsible for it. A brief history of CRISPR CRISPR – otherwise known as Clustered Regularly Interspaced Shor...

3D Genomic Maps

Cancer's Progress Detailed by 3D Genomic Maps Researchers have long known that cancer alters its genome as it evolves. What has been less clear is how, when, and why genomic structures change as cancer progresses. A new Yale study published Aug. 18 in Nature Genetics reveals critical insights and potential biomarkers of stage-specific cancer development. Using a technique called chromatin tracing, Yale researchers created detailed 3D maps of genome structures in individual cells in mouse models of lung and pancreatic cancers, driven by the cancer-causing gene KRAS. The maps reveal how chromosomes fold and genes are positioned in the cell nucleus. They also chart cancer’s route from pre-cancerous to advanced disease, even identifying different cancer cell states based solely on the 3D structure of their genomes. “Importantly, using the unprecedented 3D genome maps, we developed new ways to better nominate cancer-driving genes. These are potential new drug targets for lung cancer, th...

Deadly Inherited Diseases

8 babies spared from potentially deadly inherited diseases through new IVF 'mitochondrial donation' trial A groundbreaking trial in the U.K. has released data on eight babies born through a special IVF procedure to lower their risk of mitochondrial DNA disease. Mitochondria (pictured) carry unique DNA, but when that DNA is mutated, it can cause incurable diseases. A new trial looks at a way of lowering the risk of those conditions. (Image credit: MARK GARLICK/SCIENCE PHOTO LIBRARY via Getty Images).  Mitochondria, the powerhouses of cells, contain their own special DNA that gets passed from mother to child - but that DNA can sometimes carry mutations, causing diseases for which there are currently no cures. Now, in a new clinical trial, eight babies who had a high risk of inheriting such diseases from their moms appear to have been spared, thanks to an emerging technique called "mitochondrial donation." The approach used in the trial has been in development for many y...

Genetics Awards-Promote Video

International Research Awards on Genetics and Genomics of Diseases International Conference on Genetics and Genomics of Diseases Visit:  genetics-conferences.healthcarek.com Award Nomination:  genetics-conferences.healthcarek.com/award-nomination/?ecategory=Awards&rcategory=Awardee Award registration:  genetics-conferences.healthcarek.com/award-registration/ For Enquiries:  contact@healthcarek.com Get Connected Here --------------------------------- --------------------------------- in.pinterest.com/Dorita0211 twitter.com/Dorita_02_11_ facebook.com/profile.php?id=61555903296992 instagram.com/p/C4ukfcOsK36 genetics-awards.blogspot.com/ youtube.com/@GeneticsHealthcare linkedin.com/in/genetics-research-160337363/

Scientists Discover

“Delete-To-Recruit” – Scientists Discover Simpler Approach to Gene Therapy Repositioning genes awakens fetal hemoglobin to treat disease. CRISPR editing may change future gene therapy. Researchers have discovered a promising new approach to gene therapy by reactivating genes that are normally inactive. They achieved this by moving the genes closer to regulatory elements on the DNA known as enhancers. To do so, they used CRISPR-Cas9 technology to cut out the piece of DNA separating the gene from its enhancer. This method could open up new ways to treat genetic diseases. The team demonstrated its potential in treating sickle cell disease and beta-thalassemia, two inherited blood disorders. In these cases, a malfunctioning gene might be bypassed by reactivating an alternative gene that is usually turned off. This technique, called “delete-to-recruit,” works by altering the distance between genetic elements without introducing new genes or foreign material. The study was conducted by r...