Alzheimer's Disease Alzheimer’s Disease is a progressive neurodegenerative disorder and the most common cause of dementia, primarily affecting older adults. It is characterized by gradual memory loss, cognitive decline, impaired reasoning, and behavioral changes that interfere with daily life. Pathologically, the disease is associated with the accumulation of amyloid-β plaques and neurofibrillary tangles composed of tau protein in the brain, leading to synaptic dysfunction and neuronal death. Genetic factors , aging, lifestyle, and environmental influences contribute to disease risk. Although there is currently no cure, early diagnosis, symptomatic treatments, and ongoing research in genetics , biomarkers , and precision medicine aim to slow disease progression and improve patient quality of life. Alzheimer’s Disease, Dementia, Neurodegeneration, Amyloid Beta, Tau Protein, Cognitive Decline, Memory Loss, Brain Aging, Neuroinflammation, Synaptic Dysfunction, Genetic Risk Factors, A...
Hypoplastic Nasal Bone Hypoplastic nasal bone refers to the underdevelopment or reduced size of the fetal nasal bone , most commonly identified during prenatal ultrasound examinations in the first or second trimester. It is considered a significant soft marker for chromosomal abnormalities , particularly Down syndrome (Trisomy 21) , and may also be associated with other aneuploidies such as Trisomy 18 and Trisomy 13. While the presence of a hypoplastic nasal bone increases genetic risk, it can also be observed in normal fetuses, with prevalence varying by ethnicity. Therefore, its clinical significance is best interpreted alongside maternal age, biochemical screening, and advanced diagnostic tests such as NIPT, chorionic villus sampling (CVS), or amniocentesis . Hypoplastic nasal bone, prenatal ultrasound marker, fetal nasal bone, Down syndrome marker, Trisomy 21, aneuploidy screening, prenatal diagnosis, fetal anomalies, genetic screening #HypoplasticNasalBone #PrenatalUltr...